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Daxxify Is Here: The First Longer-Lasting Alternative to Botox

August 15, 2024
May 14, 2025
*Photos are of models, not actual patients.

The much-anticipated Daxxify neuromodulator is now available, featuring a proprietary peptide that enhances absorption for potentially 6-9 month duration compared to the typical 4-month effectiveness of traditional options like Botox, Dysport, Xeomin, and Jeuveau—while working through the same mechanism of blocking nerve signals to prevent muscle contractions that cause skin creasing, this "vegan" formula containing no animal products offers an excellent alternative for those who find Botox doesn't last long enough, though patients satisfied with their current Botox results may prefer to maintain their established treatment.

Longer Lasting Botox? Daxxify is here!

The wait is over.  Daxxify is finally here.  This new wrinkle buster was FDA approved in September.  The nationwide launch is scheduled for early 2023.  I was fortunate to be amongst the first group of physicians to have access to Daxxify as part of a prelaunch program after attending an educational and training seminar at Revance’s corporate headquarters in Nashville, TN.  We are currently using and have had great results so far.  Daxxify is unique in that it has a proprietary peptide that enhances its absorption and makes it last longer.  There are no animal products in it so it is essentially a “Vegan” drug.

Daxxify: The Revolutionary Longer-Lasting Alternative to Traditional Neuromodulators

Botox is the most popular non-surgical treatment worldwide.  It is in a class of drugs known as neuromodulators.  Historically, when done properly and by a skilled practitioner, nothing beats Botox.  Despite other neuromodulators joining the party Botox is still the king commanding about 70% of the market in the United States.  The reason it has dominated is because it is the gold standard having become a household word and none of the other neuromodulators had any significant advantages.  Daxxify or as it is also know Daxi is the first neuromodulator to last longer than Botox.

Botox, like many medical discoveries, happened accidentally.  I first learned about Botox to treat wrinkles in the late nineties.  I attended a lecture given by Dr. Jean Carruthers at the annual meeting of the American Society for Dermatologic Surgery.  Dr. Carruthers, an ophthalmologist, had been using Botox to treat patients with blepharospasm.  Blepharospasm is a condition where people have uncontrollably twitchy eyelids.  Dr. Carruthers was injecting Botox into the muscles around the eye that cause the twitching.  One of her patients came back to her telling her that she was happy that her twitching was better and she was ecstatic that the wrinkles around her eyes were softer.  She begged Dr. Carruthers to inject her forehead.  As chance would have it, Dr. Carruther’s husband is a dermatologist.  Over dinner they discussed Botox and how it could be used to treat a variety of wrinkles.  When I returned to my office I treated my nurses frown lines.  The results were like magic.  Thus, a star was born.

How Neuromodulators Work: Understanding the Science Behind Wrinkle Reduction

Daxxify joins the other FDA approved neuromdulators which include Botox,Dysport, Xeomin, and Jeuveau.  They all work in a similar fashion sort of like a mute button on a phone.  They block the signal from a nerve telling a muscle to contract.  These medicines don’t act as a fillers rather they act to prevent a muscle from repeatedly folding the skin which creases the skin.  Once you stop folding the skin, the lines soften over time.  Most people receive treatment about three times per year to maintain the results.  One of the biggest downsides of the neuromodulators prior to Daxxify is that they typically last about 4 months.  Daxxify has shown to last an average of 6 months and as long as 9 months.

Will Daxxify replace Botox?  I don’t think so.  If you’ve been happy with your Botox treatments, stick with Botox.  If you find that Botox doesn’t last long enough for you then Daxxify might be worth a shot!  In any event we are here to help.